18三体综合征合并无脑儿与羊水甲胎蛋白升高相关。
Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid.
作者信息
Merrild U, Schiøler V, Christensen F, Wolny E, Edeling C J
出版信息
Hum Genet. 1978 Nov 24;45(1):85-8. doi: 10.1007/BF00277578.
PMID:83284
Abstract
Elevated levels of alpha-1-fetoprotein (AFP) were found in the amniotic fluid of a 36-year-old woman in the 15th week of gestation. Because of this and the results of repeated ultrasonography, abortion was induced. An anencephalic fetus with trisomy 18 was delivered. The possible correlation among neural-tube defects, chromosomal abnormalities, and level of AFP is discussed.
摘要
在一名36岁女性妊娠15周时的羊水中发现甲胎蛋白（AFP）水平升高。鉴于此以及重复超声检查的结果，实施了引产。产出了一个患有18三体综合征的无脑儿胎儿。本文讨论了神经管缺陷、染色体异常和AFP水平之间可能存在的相关性。
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