Mizukawa H, Yoshida K, Honmura A, Uchiyama Y, Kaku H, Nakajima S, Haruki E
Kanagawa Rehabilitation Institute, Japan.
Am J Chin Med. 1993;21(1):71-8. doi: 10.1142/S0192415X93000091.
The inhibitory effect of Orengedokuto on lipid peroxide and sialidase was investigated using rats affected with carrageenin cotton pellet-induced granuloma and adjuvant arthritis. As a result, in the case of rats with carrageenin cotton pellet-induced granuloma, a significant inhibitory effect on granuloma formation was observed in the Orengedokuto treated rats (150 mg/kg/day) which showed a decrease in serum lipid peroxide (p < 0.001) and an increase in acid soluble glycoprotein (p < 0.001). In the case of adjuvant-induced arthritic rats, however, the condition of the arthritis was not improved at all, and was even aggravated in spite of the decrease in serum lipid peroxide.
使用角叉菜胶棉球诱导的肉芽肿和佐剂性关节炎大鼠，研究了黄连解毒汤对脂质过氧化物和唾液酸酶的抑制作用。结果，在角叉菜胶棉球诱导的肉芽肿大鼠中，黄连解毒汤治疗组（150mg/kg/天）对肉芽肿形成有显著抑制作用，血清脂质过氧化物降低（p<0.001），酸溶性糖蛋白增加（p<0.001）。然而，在佐剂性关节炎大鼠中，尽管血清脂质过氧化物减少，但关节炎状况根本没有改善，甚至加重。
