使用扫描电化学显微镜通过多孔膜进行离子电渗转运：应用于离子通量通过皮肤的体外研究。

Iontophoretic transport through porous membranes using scanning electrochemical microscopy: application to in vitro studies of ion fluxes through skin.

作者信息

Scott E R, White H S, Phipps J B

机构信息

Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis 55455.

出版信息

Anal Chem. 1993 Jun 1;65(11):1537-45. doi: 10.1021/ac00059a010.

DOI:10.1021/ac00059a010

PMID:8328671

Abstract

Scanning electrochemical microscopy (SECM) is used to map localized iontophoretic fluxes of electroactive species through porous membranes. A method is described that allows both the rate of transport of species from a microscopic pore and the pore's diameter to be measured. SECM images and analyses of synthetic porous membranes (track-etched polycarbonate and mica membranes) and hairless mouse skin are reported. Preliminary analysis of SECM images of the mouse skin indicates that a significant percentage of the iontophoretic flux occurs through pores associated with hair follicles.

摘要

扫描电化学显微镜（SECM）用于绘制电活性物质通过多孔膜的局部离子电渗通量图。本文描述了一种能够测量物质从微观孔隙中的传输速率以及孔隙直径的方法。报告了对合成多孔膜（径迹蚀刻聚碳酸酯膜和云母膜）和无毛小鼠皮肤的SECM成像及分析。对小鼠皮肤的SECM图像的初步分析表明，相当大比例的离子电渗通量是通过与毛囊相关的孔隙发生的。