14C-N-N'-二环丙基-甲基-哌嗪二盐酸盐的药代动力学。第三次通讯：口服给药后食蟹猴的全身放射自显影研究。
Pharmacokinetics of 14C-N-N'-dicyclopropyl-methyl-piperazine-dichlorhydrate. 3rd communication: whole-body autoradiographic study in Cynomolgus monkeys after oral administration.
作者信息
Benard P, Dormard Y, Houin G, Declume C, Malbosc R, Tufenkji A E, Galtier P, Alvinerie M
机构信息
Laboratoire de Radioéléments et Etudes Métaboliques, I.N.R.A. E.N.V.T., Toulouse, France.
出版信息
Arzneimittelforschung. 1993 May;43(5):516-20.
A distribution study was carried out on Cynomolgus monkeys (Macaca fascicularis) dosed orally with 14C-labelled N-N'-dicyclopropyl-methyl-piperazine-dichlor-hydrate 14C-Ino 2628-CZ and sacrificed 2, 8 and 24 h after dosage, using whole-body autoradiography. It is demonstrated that radioactivity is found in all the body; high intakes occur in melanin containing tissues, in blood-forming organs, and in accessory genital glands. Moreover, radioactivity crosses the blood-brain barrier and is mainly localized in hippocampus, caudate, putamen and frontal cortex.
对食蟹猴（猕猴）进行了分布研究，给它们口服14C标记的N-N'-二环丙基-甲基-哌嗪-二氯水合物14C-Ino 2628-CZ，并在给药后2小时、8小时和24小时处死，采用全身放射自显影技术。结果表明，全身均发现有放射性；在含黑色素的组织、造血器官和附属生殖腺中摄取量较高。此外，放射性穿过血脑屏障，主要定位于海马体、尾状核、壳核和额叶皮质。
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