Hermida R C, Ayala D E, Fernández J R, Mojón A
Bioengineering Laboratory, E.T.S.I. Telecommunicación, University of Vigo, Spain.
Biomed Instrum Technol. 1993 May-Jun;27(3):235-43.
For the study of blood pressure, the use of automatic fully ambulatory recording systems greatly facilitates data collection and, in combination with proper software, the interpretation of results. Hardware for automatic long-term measurement is here wedded to a set of software modules to assess the circadian variability of human blood pressure. To evaluate changes in blood pressure within a day, the authors analyzed 150 series of systolic and diastolic blood pressures and heart rates automatically monitored every 30 minutes for at least 48 hours. Subjects were clinically healthy men and women 19-23 years of age. Individual circadian-rhythm parameters computed for each time series by least-squares rhythmometry were used to assess rhythm characteristics of all subjects and for each gender separately. Those individual parameters were also used for the computation of a so-called paradesm, a (here 90%) time-specified prediction region for the amplitude-acrophase pair. The limits thus obtained for the circadian amplitude (an index of within-day variability) of blood pressure were exceeded in cases of amplitude-hypertension. Additionally, the original data were used to compute time-specified prediction limits for blood pressure and heart rate in clinical health. Such reference limits may serve for an objective and positive definition of health, for the screening and diagnosis of disease, and for gauging a subject's response to treatment. The combined hardware-software method for the establishment of time-qualified reference limits presented allows the assessment of the extent and timing of rhythmic change and can be used for the interpretation of single values obtained at specified times.
对于血压研究而言，使用自动全动态记录系统极大地便利了数据收集，并且与适当的软件相结合，有助于结果的解读。用于自动长期测量的硬件与一组软件模块相结合，以评估人体血压的昼夜变异性。为了评估一天内血压的变化，作者分析了150组收缩压、舒张压以及心率数据，这些数据每30分钟自动监测一次，至少持续48小时。受试者为19至23岁临床健康的男性和女性。通过最小二乘节律测定法为每个时间序列计算的个体昼夜节律参数，用于评估所有受试者以及按性别分别评估的节律特征。这些个体参数还用于计算所谓的“平行均值”，即幅度-峰相位对的（此处为90%）时间指定预测区域。在幅度性高血压病例中，血压昼夜幅度（日内变异性指标）超过了由此获得的限值。此外，原始数据用于计算临床健康状态下血压和心率的时间指定预测限值。此类参考限值可用于对健康进行客观和积极的定义、疾病的筛查和诊断以及衡量受试者对治疗的反应。所提出的用于建立时间限定参考限值的硬件-软件组合方法，能够评估节律变化的程度和时间，可用于解读在特定时间获得的单个值。
