Bredt W, Wellek B, Brunner H, Loos M
Infect Immun. 1977 Jan;15(1):7-12. doi: 10.1128/iai.15.1.7-12.1977.
Mycoplasma pneumoniae cells were rounded and killed by fresh guinea pig serum (GPS) which did not contain detectable amounts of antibody. The first component of complement (C1) was bound by M. pneumoniae in considerable amounts from both GPS and purified C1. The C1 bound by the cells was reacting with C4. Sequential addition of C1, C4, C2, and C-ethylenediaminetetraacetate to glass-grown M. pneumoniae cells resulted in rounding of a significant number of cells. M. orale and M. fermentans showed a reduced binding capacity for C1 as compared with M. pneumoniae. Both species were only slowly killed by fresh GPS, whereas M. hominis was as sensitive as M. pneumoniae. The results suggest an antibody-independent interaction between some components of the membrane surface of M. pneumoniae and C1, resulting in an activation of the complement system leading to the killing of the mycoplasma cells.
肺炎支原体细胞呈圆形，并被不含可检测抗体的新鲜豚鼠血清（GPS）杀死。来自GPS和纯化C1的相当数量的补体第一成分（C1）被肺炎支原体结合。细胞结合的C1与C4发生反应。向玻璃培养的肺炎支原体细胞中依次添加C1、C4、C2和C - 乙二胺四乙酸，导致大量细胞变圆。与肺炎支原体相比，口腔支原体和发酵支原体对C1的结合能力降低。这两个菌种仅被新鲜GPS缓慢杀死，而人型支原体与肺炎支原体一样敏感。结果表明，肺炎支原体膜表面的某些成分与C1之间存在不依赖抗体的相互作用，导致补体系统激活，从而杀死支原体细胞。
