Rothblat L A, Vnek N, Gleason T C, Kromer L F
Department of Psychology, George Washington University, Washington, DC 20052.
Behav Brain Res. 1993 May 31;55(1):93-100. doi: 10.1016/0166-4328(93)90011-e.
Rats with aspiration or excitotoxic (NMDA) lesions of the parahippocampal region were trained on a series of behavioral tasks which consisted of: (1) a test of spatial memory (discrete trial rewarded alternation), (2) a black-white discrimination, and (3) a test of non-spatial memory commonly used in primate models of amnesia (visual concurrent object discrimination). Rats in both lesion groups were severely impaired on the concurrent discrimination, even though they were able to learn the black-white discrimination normally. Animals with aspiration lesions were also impaired on the spatial memory task, whereas those with NMDA lesions did not differ from controls. The results indicate that concurrent object discrimination is a particularly sensitive measure of hippocampal/parahippocampal functions and suggest that these structures in the rat may serve mnemonic functions which are qualitatively similar to those of human and non-human primates.
对海马旁区域有吸入性或兴奋性毒性（NMDA）损伤的大鼠进行了一系列行为任务训练，这些任务包括：（1）空间记忆测试（离散试验奖励交替），（2）黑白辨别，以及（3）在灵长类失忆模型中常用的非空间记忆测试（视觉同时物体辨别）。两个损伤组的大鼠在同时辨别任务上都严重受损，尽管它们能够正常学习黑白辨别。有吸入性损伤的动物在空间记忆任务上也受损，而有NMDA损伤的动物与对照组没有差异。结果表明，同时物体辨别是海马体/海马旁区域功能的一种特别敏感的测量方法，并表明大鼠中的这些结构可能具有与人类和非人类灵长类动物在性质上相似的记忆功能。
