Ennaceur A, Aggleton J P
University of Durham, Department of Psychology, UK.
Exp Brain Res. 1994;100(1):85-92. doi: 10.1007/BF00227281.
The effects of fornix lesions were examined in an object recognition memory test based on spontaneous exploration. In the standard condition an object (A) was presented in the sample phase and then presented again in the test phase alongside a new object (B). Both fornix-transected (Fx) and control (Co) rats spent more time exploring the new object than the familiar object after retention delays of 1 min and 15 min. In two configural conditions designed to test sensitivity to reconfigured stimuli, the original sample (A) was now either re-presented alongside its rearranged version ([symbol: see text]) or, the re-arranged version itself ([symbol: see text]) was presented with a new object (B). In the first configural condition, both the Co and Fx rats spent more time exploring the reconfigured sample ([symbol: see text]) than the original version of the sample (A) following a delay of 1 min, but not 15 min. In the second configural condition, both Co and Fx rats spent more time exploring the new object (B) than the reconfigured version of the sample ([symbol: see text]) following a delay of 15 min but not 1 min. These present results do not support Sutherland and Rudy's hypothesis on hippocampal function; however, they demonstrate that memory of objects as well as memory of reconfigured objects could easily be examined in a test based on spontaneous exploratory behaviour.
在基于自发探索的物体识别记忆测试中，研究了穹窿损伤的影响。在标准条件下，在样本阶段呈现一个物体（A），然后在测试阶段再次呈现该物体，同时旁边还有一个新物体（B）。在1分钟和15分钟的保持延迟后，穹窿横断（Fx）大鼠和对照（Co）大鼠探索新物体的时间都比探索熟悉物体的时间长。在两个旨在测试对重新配置刺激敏感性的构型条件下，原始样本（A）现在要么与重新排列后的版本（[符号：见正文]）一起重新呈现，要么重新排列后的版本本身（[符号：见正文]）与一个新物体（B）一起呈现。在第一个构型条件下，在延迟1分钟而非15分钟后，Co大鼠和Fx大鼠探索重新配置后的样本（[符号：见正文]）的时间都比探索样本的原始版本（A）的时间长。在第二个构型条件下，在延迟15分钟而非1分钟后，Co大鼠和Fx大鼠探索新物体（B）的时间都比探索样本的重新配置版本（[符号：见正文]）的时间长。目前的这些结果不支持萨瑟兰和鲁迪关于海马体功能的假说；然而，它们表明，在基于自发探索行为的测试中，可以很容易地检测物体记忆以及重新配置物体的记忆。
