Cunningham C L, Niehus J S
Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098.
Behav Neurosci. 1993 Jun;107(3):468-79. doi: 10.1037//0735-7044.107.3.468.
This study examined the relationship between ethanol's thermal and motivational effects in a place conditioning task. In three experiments, male albino rats were exposed to a differential conditioning procedure that paired a distinctive tactile stimulus with ethanol (1.2 or 1.8 g/kg) or lithium chloride (3 meq/kg); a different stimulus was paired with saline. Different groups were exposed to ambient temperatures (Ta) of 5 degrees, 21 degrees or 32 degrees C during each 60-min conditioning trial. Both ethanol and lithium chloride produced hypothermia and conditioned place aversion in rats conditioned at normal Ta. Exposure to high Ta reduced drug-induced hypothermia, increased activity, and decreased conditioned place aversion. Exposure to low Ta did not enhance drug-induced hypothermia or change conditioned place aversion. In general, these findings support the suggestion that the hedonic effects of ethanol and lithium chloride interact with their thermal effects.
本研究在位置条件反射任务中考察了乙醇的热效应与动机效应之间的关系。在三个实验中，雄性白化大鼠接受了一种差异条件反射程序，该程序将一种独特的触觉刺激与乙醇（1.2或1.8克/千克）或氯化锂（3毫当量/千克）配对；另一种不同的刺激与生理盐水配对。在每次60分钟的条件反射试验期间，不同的组暴露于5摄氏度、21摄氏度或32摄氏度的环境温度（Ta）下。在正常Ta条件下进行条件反射的大鼠中，乙醇和氯化锂均导致体温过低和条件性位置厌恶。暴露于高温Ta可降低药物诱导的体温过低、增加活动并减少条件性位置厌恶。暴露于低温Ta不会增强药物诱导的体温过低或改变条件性位置厌恶。总体而言，这些发现支持以下观点，即乙醇和氯化锂的享乐效应与其热效应相互作用。
