Bertoni-Freddari C, Fattoretti P, Casoli T, Spagna C, Meier-Ruge W, Ulrich J
Center for Surgical Research, INRCA Research Department, Ancona, Italy.
Boll Soc Ital Biol Sper. 1993 Jan;69(1):57-63.
Synaptic contact zones in the dentate gyrus supragranular layer and cerebellar glomeruli of autoptic samples from adult, old and demented patients have been investigated by means of computer-assisted morphometric techniques. In physiological aging and senile dementia, the synaptic average area was significantly increased as compared with adult values in both the CNS areas investigated. Conversely, the number of contacts and their total surface contact area per unit volume of tissue were decreased. In animal models, the enlarged contact zones are reported to undergo perforations and splitting to modify synaptic connectivity. As against these assumptions, the increased synaptic size observed in our study appears to represent a compensative reaction of old and demented CNS to counteract the decrease in number and total contact area of the synaptic junctions.
利用计算机辅助形态计量学技术，对来自成年、老年和痴呆患者的尸检样本齿状回颗粒上层和小脑小球中的突触接触区进行了研究。在生理性衰老和老年痴呆中，与所研究的两个中枢神经系统区域的成年值相比，突触平均面积显著增加。相反，接触点的数量及其每单位体积组织的总表面接触面积减少。在动物模型中，据报道扩大的接触区会发生穿孔和分裂以改变突触连接性。与这些假设相反，我们研究中观察到的突触大小增加似乎代表了老年和痴呆中枢神经系统的一种补偿反应，以抵消突触连接数量和总接触面积的减少。
