Hedo C, Aken'Ova Y, Okpala I, Salimonu L
Department of Chemical Pathology, College of Medicine, University of Ibadan, Nigeria.
APMIS. 1993 May;101(5):353-7. doi: 10.1111/j.1699-0463.1993.tb00121.x.
Serum concentrations of immunoglobulins G, A, M and IgG subclasses were determined by single radial immunodiffusion assay in a population of sickle cell anaemia patients resident in the tropics. Fifty apparently healthy subjects of haemoglobin genotype AA, of comparable age, sex and socioeconomic status (SES), and in the same environment as the patients, were included as controls. Three indices of morbidity in SCA, namely frequency of crisis, degree of anaemia and the number of organ complications, were used to derive a severity score for each patient; and thus categorize the subjects into severity groups. Immunoglobulin levels were then correlated with the indices of morbidity as well as the derived severity score. IgG, IgA, IgM, IgG1 and IgG3 levels were significantly raised in the SCA subjects when they were compared as a group with the controls. When separated into disease severity groups, the mildly affected patients were found to have virtually normal levels of immunoglobulins. Total IgG concentration and level of the IgG3 subclass showed significant positive correlation with frequency of crisis and derived severity score. Markedly raised levels of IgG and IgG3 may be predictive of severity in sickle cell anaemia.
采用单向免疫扩散法测定了居住在热带地区的镰状细胞贫血患者群体血清中免疫球蛋白G、A、M及IgG亚类的浓度。选取50名血红蛋白基因型为AA、年龄、性别和社会经济地位（SES）与患者相当且与患者处于相同环境的明显健康受试者作为对照。使用镰状细胞贫血的三个发病指标，即危象发生频率、贫血程度和器官并发症数量，为每位患者得出严重程度评分；从而将受试者分为不同严重程度组。然后将免疫球蛋白水平与发病指标以及得出的严重程度评分进行关联分析。与对照组相比，镰状细胞贫血受试者组的IgG、IgA、IgM、IgG1和IgG3水平显著升高。当分为疾病严重程度组时，发现轻度受影响患者的免疫球蛋白水平基本正常。总IgG浓度和IgG3亚类水平与危象发生频率和得出的严重程度评分呈显著正相关。IgG和IgG3水平显著升高可能预示镰状细胞贫血的严重程度。
