Natta C L, Outschoorn I M
Scand J Haematol. 1984 Aug;33(2):129-34. doi: 10.1111/j.1600-0609.1984.tb02387.x.
8 patients with known sickle cell anaemia were studied immunologically. The concentrations of the main immunoglobulin classes, IgG and IgA, were significantly higher than the levels in 11 normal age- and sex-matched black subjects (P less than 0.01). IgM levels were not significantly different in the two groups. There was a heterogeneity in the interaction of the IgG subclasses with Protein A, with low levels of IgG2. The IgG2:IgG1 ratios varied from 1:3.8 to 1:6 (normals 1:3). In 4 patients the absolute levels of IgG2 as measured by radial immunodiffusion were lower than normal, thus confirming the chromatographic ratios. Since specific antibody is often restricted to a single subclass, the levels of IgG subclasses may be related to recurrent bacterial infections in these patients.
对8例已知镰状细胞贫血患者进行了免疫学研究。主要免疫球蛋白类别IgG和IgA的浓度显著高于11名年龄和性别匹配的正常黑人受试者（P<0.01）。两组的IgM水平无显著差异。IgG亚类与蛋白A的相互作用存在异质性，IgG2水平较低。IgG2:IgG1比值在1:3.8至1:6之间（正常人为1:3）。通过放射免疫扩散法测定，4例患者的IgG2绝对水平低于正常，从而证实了色谱法得出的比值。由于特异性抗体通常局限于单个亚类，因此IgG亚类的水平可能与这些患者反复发生的细菌感染有关。
