Bower C, Stanley F J, Croft M, de Klerk N, Davis R E, Nicol D J
Western Australian Research Institute for Child Health, Princess Margaret Hospital for Children.
Br J Nutr. 1993 May;69(3):827-34. doi: 10.1079/bjn19930083.
The ability to hydrolyse and absorb pteroylpolyglutamates (PteGlun) included in a standard meal in mothers who had given birth to an infant with a neural tube defect was tested by comparing them with mothers who had not had any infants with this defect. When compared with control mothers working in the research unit in which the study was performed, case mothers had significantly lower baseline serum and erythrocyte folate levels, and smaller increases in serum folate following the meal containing PteGlun. However, all estimates of folate were similar when case mothers were compared with a group of mothers who were friends of the case mothers. The results show that the higher the baseline levels of serum and erythrocyte folate the greater the increase in serum folate after the test meal. Fitting a model for the serum folate response curve resulted in coefficients which differed significantly between case mothers and all control mothers. We conclude that intestinal hydrolysis of PteGlun taken orally is not impaired in mothers who have had infants with neural tube defects when compared with control mothers with similar baseline folate levels, although the curves describing the response to the meal for the two groups do differ significantly. Further investigation is required to determine the mechanism underlying this difference.
通过将生育过神经管缺陷婴儿的母亲与未生育过此类缺陷婴儿的母亲进行比较，测试了她们水解和吸收标准餐中所含蝶酰多谷氨酸（PteGlun）的能力。与在进行该研究的研究单位工作的对照母亲相比，病例母亲的基线血清和红细胞叶酸水平显著较低，且在食用含PteGlun的餐后血清叶酸的增加幅度较小。然而，当将病例母亲与一组病例母亲的朋友进行比较时，所有叶酸估计值均相似。结果表明，血清和红细胞叶酸的基线水平越高，测试餐后血清叶酸的增加幅度就越大。对血清叶酸反应曲线拟合模型得出的系数在病例母亲和所有对照母亲之间存在显著差异。我们得出结论，与具有相似基线叶酸水平的对照母亲相比，生育过神经管缺陷婴儿的母亲口服PteGlun后的肠道水解功能并未受损，尽管两组对餐食反应的曲线确实存在显著差异。需要进一步研究以确定这种差异背后的机制。
