Anderson T J, Ryan T J, Mudge G H, Selwyn A P, Ganz P, Yeung A C
Cardiovascular Division, Brigham and Women's Hospital, Boston, MA 02115.
J Heart Lung Transplant. 1993 May-Jun;12(3):522-4.
Intracoronary adenosine was infused in 22 patients early (less than 2 months) after heart transplantation to study coronary flow reserve in the left anterior descending artery. Potentially serious bradycardia requiring discontinuation of the infusion occurred in three patients. This complication had not been noted when adenosine was given to 84 patients with at least 1 year after transplantation. Newly transplanted hearts may therefore have increased susceptibility to the bradycardic action of adenosine, which should be used with caution in this population.
在心脏移植术后早期（不到2个月），对22例患者进行冠状动脉内注射腺苷，以研究左前降支的冠状动脉血流储备。3例患者出现了需要停止注射的潜在严重心动过缓。在移植后至少1年的84例患者中给予腺苷时，未发现这种并发症。因此，新移植的心脏可能对腺苷的心动过缓作用敏感性增加，在这一人群中应谨慎使用腺苷。
