Glöckner R
Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany.
Exp Toxicol Pathol. 1993 May;45(2-3):99-100. doi: 10.1016/S0940-2993(11)80476-8.
Two models of disturbed pregnancy, both causing decreased fetal body mass, were used: the endotoxin-model (treatment of pregnant rats with heat-denaturated bacterial material) and the stress-model (chronic restraint of prenatally lithium-treated pregnant dams). Fetuses were delivered by Caesarean section in the morning of the 21st gestational day. After disturbed pregnancy lipid peroxidation (iron-stimulated formation of thiobarbituric acid reagible substances) was not changed in 9,000 g supernatant of total brain. The values of all groups were higher after determination in frozen/thawed tissue in comparison to freshly prepared material. The results do not indicate an enhanced vulnerability of brain tissue after both models of disturbed pregnancy.
内毒素模型（用热变性细菌物质处理妊娠大鼠）和应激模型（对产前用锂处理过的妊娠母鼠进行慢性束缚）。在妊娠第21天上午通过剖宫产取出胎儿。妊娠紊乱后，全脑9000g上清液中的脂质过氧化（铁刺激硫代巴比妥酸反应性物质的形成）未发生变化。与新鲜制备的材料相比，所有组在冷冻/解冻组织中测定后的数值更高。结果并未表明在这两种妊娠紊乱模型后脑组织的易损性增加。
