Braikow G, Braekow-Bruzzi S, Glöckner R, Graf R
Institute of Pharmacology and Toxicology, Friedrich-Schiller-Universität Jena, Germany.
Exp Toxicol Pathol. 1992 Sep;44(5):287-93. doi: 10.1016/S0940-2993(11)80249-6.
Treatment of pregnant rats with heat-denaturated bacterial material (endotoxin-model) or exposure to chronic restraint of prenatally lithium-treated pregnant dams (stress-model) were used as two models of disturbed pregnancy, both causing decreased fetal body mass. The quotient of fetal/placental mass was lowered in the endotoxin-group only. Placental mass and protein content were not changed significantly in both experimental groups, although a tendency to smaller placentae was noticed in the stress-group. Placental histology of the stress-group did not differ from untreated controls. In the endotoxin-group an altered structure of the placental barrier was observed. Small decreases of GSH and GSSG in the endotoxin-group and of GSSG in the stress-group without significant changes of the GSH/GSSG relationship were measured in homogenates of the placental labyrinth. Moderate enhancement of LPO concentration occurred in the endotoxin-group and more distinctly in two litters of the stress-group, the latter being connected with high GSSG concentrations and low fetal/placental mass-quotients.
用热变性细菌物质（内毒素模型）处理怀孕大鼠，或让产前接受锂治疗的怀孕母鼠长期处于束缚状态（应激模型），以此作为两种妊娠紊乱模型，二者均导致胎儿体重下降。仅在内毒素组中，胎儿/胎盘质量比降低。尽管在应激组中观察到胎盘有变小的趋势，但两个实验组的胎盘质量和蛋白质含量均无显著变化。应激组的胎盘组织学与未处理的对照组无异。在内毒素组中，观察到胎盘屏障结构改变。在内毒素组胎盘迷路匀浆中，谷胱甘肽（GSH）和氧化型谷胱甘肽（GSSG）略有下降，在应激组中GSSG下降，而GSH/GSSG关系无显著变化。在内毒素组中，脂质过氧化（LPO）浓度适度升高，在应激组的两窝中升高更为明显，后者与高GSSG浓度和低胎儿/胎盘质量比有关。
