Steininger T L, Wainer B H, Klein R, Barbacid M, Palfrey H C
University of Chicago, IL 60637.
Brain Res. 1993 May 28;612(1-2):330-5. doi: 10.1016/0006-8993(93)91681-h.
Trk-immunoreactivity was observed in basal forebrain and striatal cholinergic neurons, whereas low-affinity NGF receptor immunoreactivity was observed in basal forebrain but not striatal cholinergic neurons. Since NGF exerts trophic actions on both basal forebrain and striatal cholinergic populations, the presence of Trk in these neurons lends strong support for an essential role of Trk in NGF-responsive neurons, but suggests that the low affinity receptor is not necessary for NGF actions in the striatum.
在基底前脑和纹状体胆碱能神经元中观察到Trk免疫反应性，而在基底前脑观察到低亲和力NGF受体免疫反应性，但在纹状体胆碱能神经元中未观察到。由于NGF对基底前脑和纹状体胆碱能群体均发挥营养作用，这些神经元中Trk的存在有力支持了Trk在NGF反应性神经元中的重要作用，但表明低亲和力受体对于NGF在纹状体中的作用并非必需。
