Hopps V, Vetri P, Biondi F, Fontana G
Facoltà di Scienze MM. FF. e NN., Cattedra di Farmacologia, Università degli Studi di Palermo.
Clin Ter. 1993 Apr;142(4):311-22.
Cyclosporin A (CsA) is an immunosuppressive drug, but it has also a marked action on carbohydrate metabolism. This study was designed to define the role of a single CsA administration in glucose load distribution. Results show that CsA seems to modify glucose load distribution; in fact it influences considerably glycemia and hepatic, cardiac and muscular glycogen levels, particularly after glucose load. The present experiments suggest that CsA has an antagonist action on insulin release elicited by glucose. This effect may be due to a modification of Ca2+ cellular levels in pancreatic beta-cells. Reduction of insulin release may develop a "pharmacologic diabetes" with metabolism deviated towards gluconeogenesis.
环孢素A（CsA）是一种免疫抑制药物，但它对碳水化合物代谢也有显著作用。本研究旨在确定单次给予CsA在葡萄糖负荷分布中的作用。结果表明，CsA似乎会改变葡萄糖负荷分布；事实上，它对血糖以及肝脏、心脏和肌肉中的糖原水平有相当大的影响，尤其是在葡萄糖负荷后。目前的实验表明，CsA对葡萄糖引发的胰岛素释放具有拮抗作用。这种效应可能是由于胰腺β细胞中钙离子水平的改变。胰岛素释放的减少可能会引发一种“药物性糖尿病”，使代谢偏向糖异生。
