Alcántara M, Rodriguez R, Potenciano J L, Carrobles J L, Muñoz C, Gomez R
Department of Gastroenterology, Virgen de la Salud, Toledo, Spain.
Endoscopy. 1993 May;25(4):282-6. doi: 10.1055/s-2007-1010315.
A prospective study was carried out on 41 patients diagnosed as having Crohn's disease (CD) to evaluate the degree of upper gastrointestinal tract involvement. In 23 patients (56%), endoscopic alterations were found most frequently affecting the antrum and duodenum. Lesions encountered were: Aphthoid erosions, ulcers, thickening of folds, nodules, erythema and stenosis. Granulomas were found in biopsies in 19.5% of the patients: They were more frequent in those demonstrating endoscopic alterations (26%) than in those with normal endoscopic findings (11%). Clinical evolution was favorable with conventional treatment for CD and ranitidine, although the endoscopic lesions did not totally disappear in any cases. We conclude that upper gastrointestinal endoscopy with biopsies is useful in evaluating the extension of disease and can be of diagnostic value in cases of indeterminate colitis.
对41例诊断为克罗恩病（CD）的患者进行了一项前瞻性研究，以评估上消化道受累程度。在23例患者（56%）中，内镜改变最常累及胃窦和十二指肠。发现的病变有：口疮样糜烂、溃疡、皱襞增厚、结节、红斑和狭窄。19.5%的患者活检发现肉芽肿：在内镜有改变的患者中更常见（26%），而在内镜检查结果正常的患者中较少见（11%）。尽管内镜病变在任何病例中都未完全消失，但采用CD常规治疗和雷尼替丁治疗后临床病情好转。我们得出结论，上消化道内镜活检有助于评估疾病的范围，对不明原因结肠炎病例具有诊断价值。
