Prayson R A, Estes M L, Morris H H
Department of Anatomic Pathology, Cleveland Clinic Foundation, Ohio 44195-5138.
Epilepsia. 1993 Jul-Aug;34(4):609-15. doi: 10.1111/j.1528-1157.1993.tb00436.x.
Tumors and cortical dysplasia are associated with epilepsy, but few studies have examined the coexistence of neoplasia and dysplasia in these patients. We studied 13 patients (age 4-29 years) with recurrent seizures of 1 month to 21-year' duration (median 72 months). Ten patients were aged < 21 years. Imaging studies localized the lesion to the temporal lobe (10 patients), parietal lobe (2 patients), and frontal lobe (1 patient). Tumors included ganglioglioma (8 patients), dysembryoplastic neuroepithelial tumor (DNT) (3 patients), and low-grade astrocytoma (2 patients). Cortical dysplasia, including atypical aggregates of neurons (6 patients), multifocal loss of the cortical laminar architecture (7 patients), and neurons in the molecular layer of the cortex (3 patients) were observed near but separate from the tumor. Coexistence of certain tumors with cortical dysplasia, most frequently observed in the pediatric population, suggests a hamartomatous/dysplastic nature of the neoplasms.
肿瘤和皮质发育异常与癫痫有关，但很少有研究探讨这些患者中肿瘤形成与发育异常并存的情况。我们研究了13例患者（年龄4 - 29岁），其复发性癫痫发作持续时间为1个月至21年（中位数72个月）。10例患者年龄小于21岁。影像学检查将病变定位于颞叶（10例患者）、顶叶（2例患者）和额叶（1例患者）。肿瘤包括神经节胶质瘤（8例患者）、胚胎发育不良性神经上皮肿瘤（DNT）（3例患者）和低级别星形细胞瘤（2例患者）。在肿瘤附近但与之分离处观察到皮质发育异常，包括神经元的非典型聚集（6例患者）、皮质层状结构的多灶性缺失（7例患者）以及皮质分子层中的神经元（3例患者）。某些肿瘤与皮质发育异常并存，最常见于儿童人群，提示肿瘤具有错构瘤/发育异常的性质。
