Saruta T, Suzuki H, Shibata H
Department of Internal Medicine, School of Medicine, Keio University.
Nihon Naibunpi Gakkai Zasshi. 1993 May 20;69(5):509-19. doi: 10.1507/endocrine1927.69.5_509.
Recent increased use of ultrasonography and computed tomography (CT) has detected a substantial number of incidentally discovered adrenal tumor (incidentaloma). In our institute the discovery rate of adrenal incidentaloma per number of abdominal CT examinations was 0.43%. Those incidentalomas were incidentally found during examination for abdominal discomfort and lumbar pains or evaluation of the cause of hypertension. In the group study by the research committee on "Disorders of Adrenal Steroid Hormones" under the sponsorship of the Ministry of Health and Welfare of Japan, in 53 of 149 patients with incidentaloma, surgical resection was done during 5 years between 1983 and 1989. The pathological examination of those tumors revealed 67.9% of non-hyperfunctioning adrenocortical adenoma, 9.4% of adrenal cancer, 9.4% of ganglioneuroma, 5.7% of pheochromocytoma, 5.7% of adrenal cyst and 1.9% of myelolipoma. The criteria for resection of adrenal incidentaloma have not been established. However, tumors having a diameter of over 5 cm are generally excised in most institutes. Tumors having a diameter of between 3 cm and 5 cm are usually resected if the shape of the tumor is ambiguous and the margin of the tumor is irregular. Tumors having a diameter of less than 3 cm should be carefully followed up by abdominal CT examination every 6 months.
近年来,超声检查和计算机断层扫描(CT)的使用增多,发现了大量偶然发现的肾上腺肿瘤(偶发瘤)。在我们研究所,腹部CT检查中肾上腺偶发瘤的发现率为0.43%。这些偶发瘤是在检查腹部不适、腰痛或评估高血压病因时偶然发现的。在日本厚生省赞助的“肾上腺类固醇激素紊乱”研究委员会的分组研究中,149例偶发瘤患者中有53例在1983年至1989年的5年间接受了手术切除。对这些肿瘤的病理检查显示,67.9%为无功能肾上腺皮质腺瘤,9.4%为肾上腺癌,9.4%为神经节瘤,5.7%为嗜铬细胞瘤,5.7%为肾上腺囊肿,1.9%为肾上腺髓质脂肪瘤。肾上腺偶发瘤的切除标准尚未确立。然而,大多数机构通常会切除直径超过5cm的肿瘤。如果肿瘤形状不明确且边缘不规则,直径在3cm至5cm之间的肿瘤通常也会被切除。直径小于3cm的肿瘤应每6个月通过腹部CT检查进行仔细随访。