Prömpeler H J, Madjar H, Klosa W, du Bois A, Peukert R, Wilhelm C, Breckwoldt M
Univ.-Frauenklinik Freiburg.
Geburtshilfe Frauenheilkd. 1993 Jun;53(6):406-10. doi: 10.1055/s-2007-1022905.
From 1987 until 1992, 16 triplets and 2 quadruplets were studied by pulsed Doppler ultrasound between 17 and 36 weeks of gestation. A resistance index (RI) of the foetal aorta and umbilical artery above the 95th percentile was considered pathological. Elevated RI-values of the umbilical artery as compared to the A. cerebri media were indicative of circulatory centralisation. Intrauterine growth retardation (IUGR) was found in 9 (16%) foetuses, discordant growth occurred in 7 (39%) pregnancies. 41 (73%) of 56 foetuses survived in good health. Four of 7 foetuses with pathological Doppler findings died. The three survivors were markedly retarded. Four of 6 cases of intrauterine endangered foetuses were detected by Doppler sonography. The diagnosis of IUGR or discordant growth was based more frequently on pathological Doppler findings than on biometry and improved upon by combinations of both methods. Doppler sonography proved to be an important complementary method in the monitoring of high-grade multiple pregnancies.
1987年至1992年期间，对16例三胞胎和2例四胞胎在妊娠17至36周时进行了脉冲多普勒超声检查。胎儿主动脉和脐动脉阻力指数（RI）高于第95百分位数被视为病理性。与大脑中动脉相比，脐动脉RI值升高表明循环集中化。9例（16%）胎儿出现宫内生长受限（IUGR），7例（39%）妊娠出现生长不一致。56例胎儿中有41例（73%）健康存活。7例多普勒检查结果异常的胎儿中有4例死亡。3名幸存者明显发育迟缓。6例宫内濒危胎儿中有4例通过多普勒超声检查发现。IUGR或生长不一致的诊断更多基于病理性多普勒检查结果而非生物测量，两种方法结合可改善诊断。多普勒超声检查被证明是监测高危多胎妊娠的重要辅助方法。
