低氧性肺血管收缩对温度的依赖性。

Dependency of hypoxic pulmonary vasoconstriction on temperature.

作者信息

Benumof J L, Wahrenbrock E A

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1977 Jan;42(1):56-8. doi: 10.1152/jappl.1977.42.1.56.

DOI:10.1152/jappl.1977.42.1.56

Abstract

We studied the effect of temperature change on hypoxic pulmonary vasoconstriction. Selective hypoxia on the left lower lobe of the lung in open-chested dogs at 37 degrees C caused the electromagnetically measured blood flow to the lobe to decrease 51 +/- 5 (SE)% and its vascular resistance to increase 155 +/- 25%. Testing hypoxic response. The hypoxic response at 31.1 +/- 0.4 degrees C was only a 26 +/- 6% decrease in lobar blood flow compared to the hypoxic response at 40.0 +/- 0.5 degrees C which was a 60 +/- 5% decrease in lobar blood flow. Hypothermia itself was associated with a significant increase in pulmonary vascular resistance. We conclude that hypothermia inhibits and hyperthermia enhances hypoxic pulmonary vasoconstriction. The mechanism of inhibition may involve prehypoxic vasoconstriction.

摘要

我们研究了温度变化对缺氧性肺血管收缩的影响。在37摄氏度下对开胸狗的左下肺叶进行选择性缺氧，通过电磁测量发现，该肺叶的血流减少了51±5（标准误）%，其血管阻力增加了155±25%。测试缺氧反应。与在40.0±0.5摄氏度时的缺氧反应相比，在31.1±0.4摄氏度时的缺氧反应仅使肺叶血流减少了26±6%，而在40.0±0.5摄氏度时肺叶血流减少了60±5%。体温过低本身与肺血管阻力的显著增加有关。我们得出结论，体温过低会抑制而体温过高会增强缺氧性肺血管收缩。抑制机制可能涉及缺氧前的血管收缩。