Fuller C A, Horowitz J M, Horwitz B A
J Appl Physiol Respir Environ Exerc Physiol. 1977 Jan;42(1):74-9. doi: 10.1152/jappl.1977.42.1.74.
Upon exposure of rats to 2 G environments (achieved by centrifugation), there occurred a rapid decrease in colonic temperature (Tco) followed, after about 50 min, by a slow recovery toward precentrifugation levels. The initial drop in Tco was accompanied by decreases in hypothalamic and spinal cord temperatures and increases in tail temperature (Tta). In contrast to this anomalous response (i.e., increased heat loss (manifested by increased Tta) despite decreasing temperature at spinal and hypothalamic thermoreceptor areas) the return toward normal Tco appeared to involve appropriate thermoregulatory responses. The initial fall in Tco was decreased in magnitude by inverting the rat during acceleration, thereby suggesting that mechanical forces acting on the brain may underlie this temperature decrease. Exposure to cold during centrifugation allowed further examination of the thermoregulatory system. Unlike the initial acceleration-induced changes, the cold-evoked fall in Tco was not accompanied by increasing Tta and was modified by the environmental conditioning of the rats. These results are consistent with the view that exposure to 2 G adversely affects the thermoregulatory ability of rats challenged by cold.
将大鼠置于2G环境（通过离心实现）中后，结肠温度（Tco）迅速下降，约50分钟后，又缓慢恢复到离心前的水平。Tco的初始下降伴随着下丘脑和脊髓温度的降低以及尾部温度（Tta）的升高。与这种异常反应（即尽管脊髓和下丘脑温度感受器区域温度下降，但热损失增加（表现为Tta升高））相反，Tco恢复正常似乎涉及适当的体温调节反应。在加速过程中将大鼠倒置，可减小Tco的初始下降幅度，这表明作用于大脑的机械力可能是导致体温下降的原因。在离心过程中暴露于寒冷环境可进一步检查体温调节系统。与最初由加速引起的变化不同，寒冷诱发的Tco下降并未伴随着Tta升高，并且受到大鼠环境适应的影响。这些结果与以下观点一致，即暴露于2G会对受寒冷挑战的大鼠的体温调节能力产生不利影响。
