瑞典北部的人群研究。18. 高胆固醇血症与芬兰遗传影响之间的地理协变关系。

Population studies in northern Sweden. 18. Geographical covariation between hypercholesterolemia and Finnish genetic influence.

作者信息

Nylander P O, Asplund K, Beckman L, Stegmayr B, Johansson I

机构信息

Department of Medical Genetics, University of Umeå, Sweden.

出版信息

Hum Hered. 1993 May-Jun;43(3):147-54. doi: 10.1159/000154170.

DOI:10.1159/000154170

PMID:8330877

Abstract

The population of northern Sweden shows a marked ethnic heterogeneity and a unique distribution of disorders with a monogenic or polygenic background, among them cardiovascular diseases. We have studied variations between 23 North Swedish subpopulations (regions) with respect to hypercholesterolemia and its possible determinants including dietary factors, obesity and the degree of Finnish genetic influence. A significant regional heterogeneity was found concerning hypercholesterolemia, obesity and high consumption of 'boiled' coffee. Hypercholesterolemia showed significant geographical covariations with Finnish genetic influence and consumption of 'boiled' coffee. The results are consistent with the hypothesis that in addition to environmental factors Finnish genetic influence contributes to the development of hypercholesterolemia and thereby to the increased rate of cardiovascular disease found in northern Sweden.

摘要

瑞典北部人口呈现出显著的种族异质性以及具有单基因或多基因背景的疾病独特分布情况，其中包括心血管疾病。我们研究了瑞典北部23个亚人群（地区）在高胆固醇血症及其可能的决定因素（包括饮食因素、肥胖和芬兰基因影响程度）方面的差异。在高胆固醇血症、肥胖和“煮”咖啡的高消费量方面发现了显著的地区异质性。高胆固醇血症与芬兰基因影响以及“煮”咖啡的消费量呈现出显著的地理协变关系。这些结果与以下假设一致，即除环境因素外，芬兰基因影响促成了高胆固醇血症的发展，进而导致了瑞典北部心血管疾病发病率的上升。