Marton I J, Kiss C
Stomatologic Clinic, Medical University of Debrecen, Hungary.
Int Endod J. 1993 Mar;26(2):131-6. doi: 10.1111/j.1365-2591.1993.tb00555.x.
Sixty-three dental periapical lesions were investigated in order to study the involvement of inflammatory and immunologic reactions in the pathogenesis and maintenance of chronic apical periodontitis. Of 61 well-preserved specimens, 38 were classified as granulomatous, 3 as exudative periapical granulomas and 20 as periapical scars. The quantitative composition of T-lymphocyte subpopulation and macrophages, the proportion of IgE-producing cells compared with other immunoglobulin producing plasma cells, and the tissue distribution of IgE-producing plasma cells compared with that of mast cells were determined in the granulomatous types of granulomas using immunofluorescent, immunohistochemical and enzymehistochemical methods. The results indicated a decreased ratio of helper/inducer versus cytotoxic/suppressor T-lymphocytes, a remarkably high proportion of macrophages, a low frequency of IgE-producing plasma cells with different localization when compared with that of mast cells. These observations suggest that T-lymphocytes and macrophages may play an important role in the complex events of tissue destruction and repair taking place in the periapical region.
为研究炎症和免疫反应在慢性根尖周炎发病机制及维持过程中的作用，对63例牙尖周病变进行了研究。在61例保存良好的标本中，38例被分类为肉芽肿型，3例为渗出性根尖肉芽肿，20例为根尖瘢痕。采用免疫荧光、免疫组织化学和酶组织化学方法，对肉芽肿型病变中T淋巴细胞亚群和巨噬细胞的定量组成、产生IgE的细胞与产生其他免疫球蛋白的浆细胞的比例，以及产生IgE的浆细胞与肥大细胞的组织分布进行了测定。结果显示，辅助/诱导性T淋巴细胞与细胞毒性/抑制性T淋巴细胞的比例降低，巨噬细胞比例显著升高，产生IgE的浆细胞频率较低，且与肥大细胞相比定位不同。这些观察结果表明，T淋巴细胞和巨噬细胞可能在根尖周组织破坏和修复的复杂过程中起重要作用。
