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Neuraminic acid is alpha 2-->3 linked in the lipooligosaccharide of Neisseria meningitidis serogroup B strain 6275.在B群脑膜炎奈瑟菌6275菌株的脂寡糖中,神经氨酸以α2→3的方式连接。
J Bacteriol. 1993 Jul;175(14):4565-8. doi: 10.1128/jb.175.14.4565-4568.1993.
2
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The (alpha2-->8)-linked polysialic acid capsule and lipooligosaccharide structure both contribute to the ability of serogroup B Neisseria meningitidis to resist the bactericidal activity of normal human serum.(α2→8)连接的多聚唾液酸荚膜和脂寡糖结构都有助于B群脑膜炎奈瑟菌抵抗正常人血清杀菌活性的能力。
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Molecular mimicry of host structures by lipooligosaccharides of Neisseria meningitidis: characterization of sialylated and nonsialylated lacto-N-neotetraose (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc) structures in lipooligosaccharides using monoclonal antibodies and specific lectins.脑膜炎奈瑟菌脂寡糖对宿主结构的分子模拟:利用单克隆抗体和特异性凝集素对脂寡糖中唾液酸化和非唾液酸化乳糖-N-新四糖(Galβ1-4GlcNAcβ1-3Galβ1-4Glc)结构的表征
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Infect Immun. 1998 Dec;66(12):5939-47. doi: 10.1128/IAI.66.12.5939-5947.1998.
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Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose.脑膜炎奈瑟菌脂寡糖的唾液酸化通过掩盖乳糖-N-新四糖来抑制血清杀菌活性。
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Analysis of C3 deposition and degradation on Neisseria meningitidis and Neisseria gonorrhoeae.脑膜炎奈瑟菌和淋病奈瑟菌上C3沉积与降解的分析
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本文引用的文献

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Factors affecting expression of glycolipid tumor antigens: influence of ceramide composition and coexisting glycolipid on the antigenicity of gangliotriaosylceramide in murine lymphoma cells.影响糖脂肿瘤抗原表达的因素:神经酰胺组成和共存糖脂对小鼠淋巴瘤细胞中神经节三糖神经酰胺抗原性的影响
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Cytidine 5'-monophospho-N-acetylneuraminic acid or a related compound is the low Mr factor from human red blood cells which induces gonococcal resistance to killing by human serum.胞苷5'-单磷酸-N-乙酰神经氨酸或一种相关化合物是来自人红细胞的低分子量因子,它可诱导淋球菌对人血清杀伤产生抗性。
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Cytidine 5'-monophospho-N-acetyl neuraminic acid and a low molecular weight factor from human blood cells induce lipopolysaccharide alteration in gonococci when conferring resistance to killing by human serum.胞苷5'-单磷酸-N-乙酰神经氨酸和一种来自人血细胞的低分子量因子在赋予淋球菌对人血清杀伤的抗性时,会诱导淋球菌内脂多糖发生改变。
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Epitope expression of gonococcal lipooligosaccharide (LOS). Importance of the lipoidal moiety for expression of an epitope that exists in the oligosaccharide moiety of LOS.淋球菌脂寡糖(LOS)的表位表达。脂质部分对于存在于LOS寡糖部分的表位表达的重要性。
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Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunochemically similar to precursors of human blood group antigens. Carbohydrate sequence specificity of the mouse monoclonal antibodies that recognize crossreacting antigens on LOS and human erythrocytes.淋病奈瑟菌和脑膜炎奈瑟菌的脂寡糖(LOS)具有在免疫化学上与人类血型抗原前体相似的成分。识别LOS和人类红细胞上交叉反应抗原的小鼠单克隆抗体的碳水化合物序列特异性。
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Structure of the L5 lipopolysaccharide core oligosaccharides of Neisseria meningitidis.脑膜炎奈瑟菌L5脂多糖核心寡糖的结构
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Structural determination of oligosaccharides derived from lipooligosaccharide of Neisseria gonorrhoeae F62 by chemical, enzymatic, and two-dimensional NMR methods.采用化学、酶法及二维核磁共振方法对淋病奈瑟菌F62脂寡糖衍生的寡糖进行结构测定。
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Endogenous sialylation of the lipooligosaccharides of Neisseria meningitidis.脑膜炎奈瑟菌脂寡糖的内源性唾液酸化作用。
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In vitro and in vivo modification of Neisseria gonorrhoeae lipooligosaccharide epitope structure by sialylation.通过唾液酸化对淋病奈瑟菌脂寡糖表位结构进行体外和体内修饰。
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Growth of Neisseria gonorrhoeae in CMP-N-acetylneuraminic acid inhibits nonopsonic (opacity-associated outer membrane protein-mediated) interactions with human neutrophils.淋病奈瑟菌在胞苷二磷酸-N-乙酰神经氨酸中的生长抑制了与人类中性粒细胞的非调理素性(不透明相关外膜蛋白介导)相互作用。
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在B群脑膜炎奈瑟菌6275菌株的脂寡糖中,神经氨酸以α2→3的方式连接。

Neuraminic acid is alpha 2-->3 linked in the lipooligosaccharide of Neisseria meningitidis serogroup B strain 6275.

作者信息

Yamasaki R, Griffiss J M, Quinn K P, Mandrell R E

机构信息

Department of Laboratory Medicine, University of California, San Francisco 94121.

出版信息

J Bacteriol. 1993 Jul;175(14):4565-8. doi: 10.1128/jb.175.14.4565-4568.1993.

DOI:10.1128/jb.175.14.4565-4568.1993
PMID:8331087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC204901/
Abstract

We have analyzed the sialylated lipooligosaccharide of Neisseria meningitidis 6275. Sialylated oligosaccharide released from strain 6275 lipooligosaccharide by mild hydrolysis was determined to contain N-acetylneuraminic acid linked alpha 2-->3 to terminal galactose as shown below. [formula: see text]

摘要

我们分析了脑膜炎奈瑟菌6275的唾液酸化脂寡糖。通过温和水解从菌株6275脂寡糖中释放的唾液酸化寡糖经测定含有以α 2→3连接到末端半乳糖的N-乙酰神经氨酸,如下所示。[化学式:见原文]