Sano T, Sakurai M, Dohi S, Oyama A, Murota K, Sugiyama H, Miura Y, Kusuoka K, Kurata K
Department of Orthopaedic Surgery, School of Medicine, Tohoku University.
Jpn J Antibiot. 1993 Feb;46(2):159-63.
A solution of 0.5 g of meropenem (MEPM) in 100 ml of saline was administered to adult patients before the orthopaedic surgery via intravenous drip infusion for 30 minutes. Eleven samples of bone marrow blood, 13 bone, 8 joint fluid and 8 joint tissues obtained from 15 clinical cases were analyzed for MEPM levels. At the same time, blood samples were taken from peripheral veins and serum served as control was analyzed. The concentration of MEPM in the marrow blood at 30 minutes after administration of MEPM reached 15.4 micrograms/ml, which was above 50% of the maximum concentration in serum. Ratios of concentration in bone marrow to that in serum were between 93% and 105% at that time. MEPM levels were 5.74-0.40 micrograms/g in bones, 20.3-4.55 micrograms/ml in joint fluid and 18.2-4.05 micrograms/g in joint tissues at 30 to 75 minutes after administration. In joint fluid and joint tissues, the concentration above 50% of maximum level in serum were maintained for more than an hour. MEPM is thought to be useful for the treatment of bone and joint infections and also prophylaxis of infections in cases of major surgery of skeletal tissue in the field of orthopaedic surgery.
在骨科手术前，将0.5克美罗培南（MEPM）溶于100毫升生理盐水中，通过静脉滴注给药30分钟，用于成年患者。对从15例临床病例中获取的11份骨髓血、13份骨组织、8份关节液和8份关节组织样本进行了美罗培南水平分析。同时，从外周静脉采集血样并分析用作对照的血清。美罗培南给药30分钟后，骨髓血中美罗培南浓度达到15.4微克/毫升，高于血清中最大浓度的50%。此时骨髓与血清中的浓度比在93%至105%之间。给药30至75分钟后，骨组织中美罗培南水平为5.74 - 0.40微克/克，关节液中为20.3 - 4.55微克/毫升，关节组织中为18.2 - 4.05微克/克。在关节液和关节组织中，高于血清最大水平50%的浓度维持了一个多小时。美罗培南被认为可用于治疗骨与关节感染，也可预防骨科领域骨骼组织大手术中的感染。
