Hasegawa S, Numasaki K, Sato T
Department of Orthopaedic Surgery, Aizu General Hospital, Hukushima.
Jpn J Antibiot. 1990 Jan;43(1):40-6.
Cefpiramide (CPM) 2 g was preoperatively administered to 29 patients by intravenous drip infusion for 20 minutes. Concentrations of CPM in bone marrow blood, peripheral blood, and bone tissue were determined at 30, 60, 120, 180, 240 and 360 minutes after CPM administration. Mean concentrations of CPM in peripheral blood, bone marrow blood were peaked at 60 minutes after injection, those in bone tissues (cortex, cancellous bone) peaked at 30 minutes after injection. The mean ratio of the CPM concentration in bone marrow blood to peripheral blood was 105.5%, that in cortex (/g) to peripheral blood (/ml) was 17.7%, and that in cancellous bone (/g) to peripheral blood was 18.2%. These concentrations were maintained above MIC80 for 6 hours. From the above results, CPM appears useful for the prevention of infection in orthopaedic operation (skeletal surgery).
对29例患者术前静脉滴注头孢匹胺（CPM）2g，滴注时间为20分钟。在给予CPM后30、60、120、180、240和360分钟测定骨髓血、外周血和骨组织中CPM的浓度。外周血、骨髓血中CPM的平均浓度在注射后60分钟达到峰值，骨组织（皮质骨、松质骨）中的CPM平均浓度在注射后30分钟达到峰值。骨髓血中CPM浓度与外周血的平均比值为105.5%，皮质骨（/g）与外周血（/ml）的比值为17.7%，松质骨（/g）与外周血的比值为18.2%。这些浓度在6小时内维持在80% MIC以上。根据上述结果，CPM似乎对预防骨科手术（骨骼手术）感染有用。
