Dimitrov T G
Nivalinpharma, Sofia, Bulgaria.
Methods Find Exp Clin Pharmacol. 1993 Apr;15(3):189-92.
The effects of mesocarb-theophylline combination given p.o. for 30 days on plasma levels of gonadal and gonadotropic hormones (testosterone, estradiol, progesterone, FSH, LH and prolactin) were studied in male and female Wistar rats and compared to the effects of the drugs given alone. In male animals theophylline alone and mesocarb-theophylline combination did not affect normal plasma concentrations of hormones. Mesocarb alone (20 mg/kg) slightly lowered FSH levels, but with the addition of 100 mg/kg theophylline, levels returned to normal. The effects of mesocarb on FSH levels in female animals were similar but slightly stronger. In addition to its effects on FSH, a decrease in prolactin levels was also observed. These changes were not pathological while there were no changes in estradiol and progesterone levels. The combination mesocarb-theophylline prevented the oppressive effect of mesocarb on FSH secretion, did not alter FSH, LH and prolactin secretion from the adenohypophysis, and did not alter the levels of the gonadal hormones estradiol and progesterone in female animals and testosterone in males.
研究了口服美索卡与茶碱组合30天对雄性和雌性Wistar大鼠血浆中性腺激素和促性腺激素（睾酮、雌二醇、孕酮、促卵泡激素、促黄体生成素和催乳素）水平的影响，并与单独给药的效果进行了比较。在雄性动物中，单独使用茶碱和美索卡与茶碱的组合均未影响激素的正常血浆浓度。单独使用美索卡（20mg/kg）可使促卵泡激素水平略有降低，但加入100mg/kg茶碱后，水平恢复正常。美索卡对雌性动物促卵泡激素水平的影响相似但稍强。除了对促卵泡激素的影响外，还观察到催乳素水平降低。这些变化并非病理性的，而雌二醇和孕酮水平没有变化。美索卡与茶碱的组合可防止美索卡对促卵泡激素分泌的抑制作用，不改变腺垂体促卵泡激素、促黄体生成素和催乳素的分泌，也不改变雌性动物的性腺激素雌二醇和孕酮水平以及雄性动物的睾酮水平。
