Shimoda S I, Kasai K, Kikuchi T, Ieiri T
J Clin Endocrinol Metab. 1977 Jan;44(1):137-41. doi: 10.1210/jcem-44-1-137.
Tracer doses of 131I- (Carrier free), 131I-T3 and 131-T4 were administered po to 19 healthy male volunteers at intervals 2 to 8 weeks to study whether or not part of the iodide generated in the kidney from T3 and T4 deiodination may enter the renal tubular lumen and be excreted in the urine without entering the blood stream. U(urine)/T(thyroid) ratios of the radioactivity from these materials were employed as the index of the comparison. U/T ratios were severalfold higher 24 h after 131I-T3 or 131I-T4 administration than after 131I-. The data indicate that the 131I- derived from T3 and T4 metabolism is more readily excreted into urine than 131I- which reaches the kidney as inorganic iodide.
给19名健康男性志愿者口服微量示踪剂量的无载体131I、131I - T3和131I - T4，间隔2至8周，以研究由T3和T4脱碘作用在肾脏中生成的部分碘化物是否可能进入肾小管腔并在不进入血流的情况下随尿液排出。以这些物质放射性的尿（U）/甲状腺（T）比值作为比较指标。给予131I - T3或131I - T4后24小时的U/T比值比给予131I后高几倍。数据表明，由T3和T4代谢产生的131I比以无机碘形式到达肾脏的131I更容易排泄到尿液中。
