[甲状腺激素过量给药后大鼠体内的脱碘酶活性]
[Deiodase activity in rats following an overdose of thyroid hormone].
作者信息
Voss C, Hartmann N, Hübner G
出版信息
Endokrinologie. 1975 Aug;65(3):320-7.
The L-DIT and L-T4 deiodinating activity in supernatants from liver or kidney homogenates of normal rats or rats loaded with T4, T3 or TSH, was investigated. Deiodination of L-DIT occurs in liver supernatants twice as much as in liver, referring to mg of protein of g of tissue, while the deiodination of L-T4 seems rather equal. The over all rate of deiodination, however, reaches in liver for L-DIT the threefold, for L-T4 the fivefold value, as compared with kidney. Short periods of loading do not alter deiodination of L-DIT in liver or kidney at all; but lead to significant elevation of L-T4-deiodination in liver tissue. Higher doses or longer periods of loading cause a significant rise of L-DIT-deiodination in liver and kidney, while the L-T4-deiodination in liver is significantly decreased and in kidney significantly elevated.
研究了正常大鼠或负荷 T4、T3 或促甲状腺激素（TSH）的大鼠肝脏或肾脏匀浆上清液中 L - 二碘甲状腺原氨酸（L - DIT）和 L - 甲状腺素（L - T4）的脱碘活性。就每克组织的蛋白质毫克数而言，肝脏上清液中 L - DIT 的脱碘量是肝脏中的两倍，而 L - T4 的脱碘量似乎相当。然而，与肾脏相比，肝脏中 L - DIT 的总体脱碘速率达到其三倍，L - T4 的脱碘速率达到其五倍。短时间负荷根本不会改变肝脏或肾脏中 L - DIT 的脱碘情况；但会导致肝脏组织中 L - T4 脱碘显著升高。更高剂量或更长时间的负荷会导致肝脏和肾脏中 L - DIT 脱碘显著升高，而肝脏中 L - T4 的脱碘显著降低，肾脏中则显著升高。
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