Prescott C A, Gottesman I I
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond.
Psychiatr Clin North Am. 1993 Jun;16(2):245-67.
Family, twin, and adoption studies have firmly established the genetic basis for a majority of cases of schizophrenia. Several other psychiatric disorders probably represent alternative manifestations of this genetic liability. The underlying genetic mechanisms are not yet well understood, but the development of schizophrenia appears to involve a system of genes that interact with pre- and postnatal stressors. Recent reports of genetic linkage in schizophrenia have not been replicated, but the potential of molecular genetic technology makes us optimistic that the bases of this complex disorder will be uncovered in the near future.
家族、双胞胎及收养研究已确凿地证实了大多数精神分裂症病例的遗传基础。其他几种精神疾病可能是这种遗传易感性的不同表现形式。潜在的遗传机制尚未被充分理解，但精神分裂症的发展似乎涉及一个与产前和产后应激源相互作用的基因系统。最近关于精神分裂症基因连锁的报告尚未得到重复验证，但分子遗传技术的潜力让我们乐观地认为，这种复杂疾病的病因将在不久的将来被揭示。
