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精神疾病遗传咨询的疗效:一项荟萃分析。

The Efficacy of Genetic Counseling for Psychiatric Disorders: a Meta-Analysis.

作者信息

Moldovan Ramona, Pintea Sebastian, Austin Jehannine

机构信息

Department of Psychology, Babes-Bolyai University, 37 Republicii St, 400015, Cluj-Napoca, Romania.

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

出版信息

J Genet Couns. 2017 Dec;26(6):1341-1347. doi: 10.1007/s10897-017-0113-8. Epub 2017 Jun 14.

Abstract

Psychiatric illnesses are complex, highly heritable disorders that have substantial implications for both affected individuals and their families. Though genetic testing is currently limited in its clinical usefulness in this area, interest in genetic counseling for psychiatric disorders has a relatively long history and many positive outcomes have been posited. Yet, empirical studies of genetic counseling outcomes have been emerging only more recently. The aim of the current meta-analysis was to analyze the efficacy of genetic counseling and explore potential moderators of its effect. An extensive electronic search was conducted investigating the literature published until July 2016. The initial search resulted in 2367 articles, four of which met the inclusion criteria and were included in the quantitative meta-analysis. Effect size parameters and sample sizes for all variables in each study were included. The efficacy has ben demonstrated both at post-intervention and at follow up, with an overall statistically significant effect size of moderate intensity. Implications of this study are discussed in detail.

摘要

精神疾病是复杂的、高度可遗传的疾病,对受影响的个体及其家庭都有重大影响。尽管目前基因检测在该领域的临床实用性有限,但对精神疾病遗传咨询的兴趣由来已久,并且已经提出了许多积极的结果。然而,关于遗传咨询结果的实证研究直到最近才出现。当前荟萃分析的目的是分析遗传咨询的效果,并探索其效果的潜在调节因素。进行了广泛的电子搜索,调查截至2016年7月发表的文献。初步搜索得到2367篇文章,其中4篇符合纳入标准并被纳入定量荟萃分析。纳入了每项研究中所有变量的效应量参数和样本量。干预后和随访时均显示出疗效,总体效应量具有统计学意义,强度为中等。详细讨论了本研究的意义。

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