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糖尿病母亲胎盘膜上受体对胰岛素的结合减少。

Decreased binding of insulin by receptors on placental membranes from diabetic mothers.

作者信息

Harrison L C, Billington T, Clark S, Nichols R, East I, Martin F I

出版信息

J Clin Endocrinol Metab. 1977 Jan;44(1):206-9. doi: 10.1210/jcem-44-1-206.

DOI:10.1210/jcem-44-1-206
PMID:833260
Abstract

Specific binding of insulin to microsomal membranes from the placentae of insulin-dependent diabetics was significantly decreased when compared with normals. This was due to an apparent decrease in the concentration of insulin receptors.

摘要

与正常人相比，胰岛素依赖型糖尿病患者胎盘微粒体膜上胰岛素的特异性结合显著降低。这是由于胰岛素受体浓度明显降低所致。

相似文献

1
Decreased binding of insulin by receptors on placental membranes from diabetic mothers.糖尿病母亲胎盘膜上受体对胰岛素的结合减少。
J Clin Endocrinol Metab. 1977 Jan;44(1):206-9. doi: 10.1210/jcem-44-1-206.
2
Insulin receptor interaction in human placental plasma membranes.人胎盘质膜中的胰岛素受体相互作用。
Rev Esp Fisiol. 1981 Sep;37(3):269-76.
3
Altered placental insulin and insulin-like growth factor-I receptors in diabetes.
Life Sci. 1988;42(17):1603-14. doi: 10.1016/0024-3205(88)90439-0.
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Placental glycogen metabolism in diabetic pregnancy.糖尿病妊娠中的胎盘糖原代谢
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Effects of metformin treatment on erythrocyte insulin binding in normal weight subjects, in obese non diabetic subjects, in type 1 and type 2 diabetic patients.二甲双胍治疗对正常体重受试者、肥胖非糖尿病受试者、1型和2型糖尿病患者红细胞胰岛素结合的影响。
Diabete Metab. 1986 Aug;12(4):219-24.
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Familial hyperinsulinemia complicated by extreme insulin resistance during pregnancy: a probable postreceptor defect.家族性高胰岛素血症在孕期并发严重胰岛素抵抗：一种可能的受体后缺陷。
J Clin Endocrinol Metab. 1985 Jul;61(1):68-77. doi: 10.1210/jcem-61-1-68.
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Effect of gestational diabetes on insulin receptors in human placenta.妊娠期糖尿病对人胎盘胰岛素受体的影响。
Diabetologia. 1979 Feb;16(2):87-91. doi: 10.1007/BF01225455.
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The effect of insulin on oestradiol and progesterone release by normal and diabetic placentae in vitro.胰岛素对正常及糖尿病胎盘体外释放雌二醇和孕酮的影响。
Placenta. 1987 Jul-Aug;8(4):443-8. doi: 10.1016/0143-4004(87)90072-5.
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Insulin action on the human placental endothelium in normal and diabetic pregnancy.胰岛素对正常和糖尿病妊娠人胎盘内皮的作用。
Curr Vasc Pharmacol. 2009 Oct;7(4):460-6. doi: 10.2174/157016109789043973.
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[Lipid-proteinic interaction in erythrocytie and placental membranes in women with insulin resistance].胰岛素抵抗女性红细胞膜和胎盘膜中的脂质-蛋白质相互作用
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引用本文的文献

1
Sex-Specific Neurodevelopmental Programming by Placental Insulin Receptors on Stress Reactivity and Sensorimotor Gating.胎盘胰岛素受体对应激反应和感觉运动门控的性别特异性神经发育编程。
Biol Psychiatry. 2017 Jul 15;82(2):127-138. doi: 10.1016/j.biopsych.2016.12.025. Epub 2016 Dec 30.
2
Features of insulin receptor interaction in placenta from normal, overt and poorly controlled gestational diabetic patients.正常、显性及控制不佳的妊娠糖尿病患者胎盘胰岛素受体相互作用的特征
Mol Cell Biochem. 1993 Sep 22;126(2):135-42. doi: 10.1007/BF00925691.
3
Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.
糖尿病孕妇所生巨大儿胎盘微绒毛膜囊泡中系统A氨基酸转运体活性的改变。
J Clin Invest. 1994 Aug;94(2):689-95. doi: 10.1172/JCI117386.
4
Changes in insulin receptor functions of the erythrocyte by treatment of non-insulin-dependent diabetes mellitus (NIDDM) patients with glibenclamide and diet control.用格列本脲和饮食控制治疗非胰岛素依赖型糖尿病（NIDDM）患者对红细胞胰岛素受体功能的影响。
Acta Diabetol Lat. 1986 Jul-Sep;23(3):233-8. doi: 10.1007/BF02624709.
5
Insulin binding to trophoblast plasma membranes and placental glycogen content in well-controlled gestational diabetic women treated with diet or insulin, in well-controlled overt diabetic patients and in healthy control subjects.胰岛素与饮食或胰岛素治疗的血糖控制良好的妊娠糖尿病妇女、血糖控制良好的显性糖尿病患者以及健康对照者的滋养层细胞膜结合及胎盘糖原含量。
Diabetologia. 1992 Jan;35(1):45-55. doi: 10.1007/BF00400851.
6
Effect of gestational diabetes on insulin receptors in human placenta.妊娠期糖尿病对人胎盘胰岛素受体的影响。
Diabetologia. 1979 Feb;16(2):87-91. doi: 10.1007/BF01225455.