佐林格-埃利森综合征中的胃排空与分泌
Gastric emptying and secretion in Zollinger-Ellison syndrome.
作者信息
Dubois A, Eerdewegh P V, Gardner J D
出版信息
J Clin Invest. 1977 Feb;59(2):255-63. doi: 10.1172/JCI108636.
Gastric emptying and secretion, as well as intragastric volume and composition, were determined simultaneously in three patients with Zollinger-Ellison syndrome and in seven normal subjects. Gastric hypersecretion was observed in patients with Zollinger-Ellison syndrome and in normal subjects receiving pentagastrin. In contrast, the fraction of gastric contents emptied per minute (fractional rate of emptying) was increased in Zollinger-Ellison patients and unchanged or decreased in normal subjects receiving pentagastrin. The increased fractional rate of gastric emptying in patients with Zollinger-Ellison syndrome persisted despite abolition of gastric hypersecretion by metiamide. Thus, the increased fractional gastric emptying seen in patients with Zollinger-Ellison syndrome is not attributable to hypergastrinemia, or to gastric hypersecretion per se. Instead, it appears to be caused by an undefined nervous or humoral factor.
在三名佐林格-埃利森综合征患者和七名正常受试者中，同时测定了胃排空和分泌情况，以及胃内体积和成分。在佐林格-埃利森综合征患者以及接受五肽胃泌素的正常受试者中观察到胃酸分泌过多。相比之下，佐林格-埃利森综合征患者每分钟胃内容物排空分数（排空分数率）增加，而接受五肽胃泌素的正常受试者该分数不变或降低。尽管甲硫咪特消除了胃酸分泌过多的情况，但佐林格-埃利森综合征患者胃排空分数率仍持续升高。因此，佐林格-埃利森综合征患者胃排空分数增加并非归因于高胃泌素血症或胃酸分泌过多本身。相反，它似乎是由一种未明确的神经或体液因素引起的。
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