C激酶可能参与蛛网膜下腔出血后慢性脑血管痉挛的发生。

Possible involvement of C-kinase in occurrence of chronic cerebral vasospasm after subarachnoid hemorrhage.

作者信息

Matsui T, Takuwa Y, Kaizu H, Asano T

机构信息

Department of Neurosurgery, Saitama Medical Center/School, Japan.

出版信息

Adv Exp Med Biol. 1993;331:177-82. doi: 10.1007/978-1-4615-2920-0_28.

DOI:10.1007/978-1-4615-2920-0_28

PMID:8333332

Abstract

The present study aimed to examine the turnover of phospholipids such as PI, PC and PE, the time course of PKC activity and the phosphorylation of 20 kDa MLC in the canine BA undergoing chronic VS. The phosphorylation of 20 kDa MLC was not augmented in the spastic BA. Turnover of PC and PE was detectably stimulated on day 7. The cytosolic PKC activity was down-regulated on days 4 and 7, while the membrane PKC activity remained unchanged during these periods. The present results indicate that a process which affected the membrane lipid metabolism, PKC metabolism and PKC activity occurred in spastic BA.

摘要

本研究旨在检测犬慢性胆管狭窄时磷脂（如磷脂酰肌醇、磷脂酰胆碱和磷脂酰乙醇胺）的周转率、蛋白激酶C（PKC）活性的时程变化以及20 kDa肌球蛋白轻链（MLC）的磷酸化情况。在痉挛性胆管中，20 kDa MLC的磷酸化并未增强。在第7天可检测到磷脂酰胆碱和磷脂酰乙醇胺的周转率受到刺激。胞质PKC活性在第4天和第7天下调，而在此期间膜PKC活性保持不变。目前的结果表明，痉挛性胆管中发生了一个影响膜脂代谢、PKC代谢和PKC活性的过程。