印度尼西亚的细菌性阴道病与早产：孕早期和孕晚期的关联
Bacterial vaginosis and prematurity in Indonesia: association in early and late pregnancy.
作者信息
Riduan J M, Hillier S L, Utomo B, Wiknjosastro G, Linnan M, Kandun N
机构信息
Division of Sexually Transmitted Diseases/Human Immunodeficiency Virus Prevention, Centers for Disease Control, Atlanta, GA 30333.
出版信息
Am J Obstet Gynecol. 1993 Jul;169(1):175-8. doi: 10.1016/0002-9378(93)90157-e.
OBJECTIVE
Our objective was to examine the association between preterm delivery and bacterial vaginosis in early and late pregnancy.
STUDY DESIGN
We evaluated 490 pregnant women at three hospitals in Jakarta, Indonesia, for bacterial vaginosis at 16 to 20 weeks' and 28 to 32 weeks' gestation and observed them through delivery.
RESULTS
We found significant associations between preterm delivery (gestational age < 37 weeks) and bacterial vaginosis diagnosed at 16 to 20 weeks' gestation (odds ratio 2.0, 95% confidence interval 1.0 to 3.9) but not with bacterial vaginosis diagnosed at 28 to 32 weeks' gestation (odds ratio 1.5, 95% confidence interval 0.7 to 3.0). The rates of preterm delivery were almost doubled for women who had bacterial vaginosis in early pregnancy (20.5%) as compared with women who had bacterial vaginosis only in late pregnancy (10.7%).
CONCLUSION
Only bacterial vaginosis diagnosed early in the second trimester of pregnancy plays a major role as a risk factor for preterm delivery.
目的
我们的目的是研究早产与妊娠早期和晚期细菌性阴道病之间的关联。
研究设计
我们在印度尼西亚雅加达的三家医院对490名孕妇进行了评估，在妊娠16至20周以及28至32周时检测她们是否患有细菌性阴道病，并观察她们直至分娩。
结果
我们发现早产（孕周<37周）与妊娠16至20周时诊断出的细菌性阴道病之间存在显著关联（比值比2.0，95%置信区间1.0至3.9），但与妊娠28至32周时诊断出的细菌性阴道病无显著关联（比值比1.5，95%置信区间0.7至3.0）。与仅在妊娠晚期患有细菌性阴道病的女性（10.7%）相比，妊娠早期患有细菌性阴道病的女性早产率几乎翻倍（20.5%）。
结论
只有在妊娠中期早期诊断出的细菌性阴道病作为早产的危险因素起主要作用。
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