Grummer M A, Langhough R E, Zachman R D
Department of Pediatrics, University of Wisconsin-Meriter Perinatal Center, Madison 53715.
Alcohol Clin Exp Res. 1993 Jun;17(3):592-7. doi: 10.1111/j.1530-0277.1993.tb00805.x.
Fetal embryo, head, and brain tissue from different gestational ages were analyzed for retinol content, nuclear retinoic acid receptor and cytosolic retinoic acid binding protein levels after maternal ethanol ingestion and compared with fetal levels in control diet pregnancies. Retinol levels in fetal embryo and brain of ethanol-ingesting pregnancies were 2- to 3-fold higher than fetal embryo and brain retinol of control pregnancies. Nuclear retinoic acid receptor was lower in 10-day embryo of ethanol pregnancies and apparently unaffected in fetal head and brain by maternal ethanol consumption at other days of gestation. In fetal head there was a significant overall ethanol effect on cytosolic retinoic acid binding protein, with increased levels in fetal tissue from ethanol-consuming pregnancies. These observations of altered embryo, fetal head, and fetal brain retinol and receptor protein levels support the hypothesis of a possible role of vitamin A in fetal alcohol syndrome.
对来自不同孕周的胎儿胚胎、头部和脑组织进行分析，测定母体摄入乙醇后其中视黄醇的含量、细胞核视黄酸受体和胞质视黄酸结合蛋白的水平，并与对照组饮食妊娠的胎儿水平进行比较。摄入乙醇的妊娠中胎儿胚胎和脑内的视黄醇水平比对照组妊娠的胎儿胚胎和脑内视黄醇水平高2至3倍。乙醇妊娠10天胚胎中的细胞核视黄酸受体较低，而在妊娠其他天数，母体摄入乙醇对胎儿头部和脑内该受体显然没有影响。在胎儿头部，乙醇对胞质视黄酸结合蛋白有显著的总体影响，摄入乙醇的妊娠胎儿组织中该蛋白水平升高。这些关于胚胎、胎儿头部和胎儿脑内视黄醇及受体蛋白水平改变的观察结果支持了维生素A在胎儿酒精综合征中可能起作用的假说。
