Bowler I M, Green J H, Wolfe S P, Littlewood J M
Regional Cystic Fibrosis Unit, St James's University Hospital, Leeds.
Arch Dis Child. 1993 Jun;68(6):754-9. doi: 10.1136/adc.68.6.754.
The resting energy expenditure (REE) and substrate oxidation rates in 16 patients with cystic fibrosis who had mild chest disease and 11 healthy controls were measured using indirect calorimetry. The mean REE (% predicted) in the patients with cystic fibrosis was 11% greater than in the controls. Five patients with cystic fibrosis were hypermetabolic but only one of these had a clinically significant reduction of respiratory function. A greater proportion of REE was derived from carbohydrate oxidation in the cystic fibrosis patients (43.5% v 29.9%). However, the 24 hour dietary intake of carbohydrate was greater in the cystic fibrosis group (49.6 v 45.8% of energy intake). These data suggest that a high dietary intake of carbohydrate may contribute to the increased oxidation of carbohydrate in these cystic fibrosis patients. All patients with cystic fibrosis, including those with apparently mild lung disease, should continue to receive a high energy diet.
采用间接测热法测量了16例患有轻度胸部疾病的囊性纤维化患者和11名健康对照者的静息能量消耗（REE）及底物氧化率。囊性纤维化患者的平均REE（预测值百分比）比对照组高11%。5例囊性纤维化患者代谢亢进，但其中只有1例呼吸功能有临床上显著的降低。囊性纤维化患者中，REE有更大比例来自碳水化合物氧化（43.5%对29.9%）。然而，囊性纤维化组的碳水化合物24小时饮食摄入量更高（占能量摄入的49.6%对45.8%）。这些数据表明，高碳水化合物饮食摄入可能导致这些囊性纤维化患者碳水化合物氧化增加。所有囊性纤维化患者，包括那些肺部疾病明显较轻的患者，都应继续接受高能量饮食。
