Ojamaa K, Balkman C, Klein I L
Department of Medicine, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030.
Ann Thorac Surg. 1993 Jul;56(1 Suppl):S61-6; discussion S66-7. doi: 10.1016/0003-4975(93)90556-w.
Thyroid hormone has profound effects on the heart and cardiovascular system. Systemic vascular resistance is uniformly decreased in both naturally occurring and experimental hyperthyroidism, and it is increased in thyroid hormone deficiency. Because vascular smooth muscle cell contraction is a major determinant of systemic vascular resistance, the present studies were designed to address the acute effects of the thyroid hormones, specifically triiodothyronine, on vascular smooth muscle cell contractile activity. Our data indicate that triiodothyronine causes smooth muscle relaxation; this property may account for some of its marked effects on the cardiovascular system. As a novel vasodilatory agent, the potential therapeutic implications for triiodothyronine may be numerous.
甲状腺激素对心脏和心血管系统有深远影响。在自然发生的和实验性甲状腺功能亢进症中，全身血管阻力均一致降低，而在甲状腺激素缺乏时则升高。由于血管平滑肌细胞收缩是全身血管阻力的主要决定因素，因此本研究旨在探讨甲状腺激素，特别是三碘甲状腺原氨酸对血管平滑肌细胞收缩活性的急性影响。我们的数据表明，三碘甲状腺原氨酸可引起平滑肌舒张；这一特性可能解释了其对心血管系统的一些显著影响。作为一种新型血管扩张剂，三碘甲状腺原氨酸可能具有众多潜在的治疗意义。
