Carbarns N J, Neale M L, Stark J M
Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, UK.
Int J Exp Pathol. 1993 Jun;74(3):309-15.
Groups of mice were given oestrone acetate or vitamin E subcutaneously to determine how these treatments might modify responses to endotoxic lipopolysaccharide given intraperitoneally. Release of hepatic transaminase and tumour necrosis factor (TNF) into serum and induction of manganous superoxide dismutase in the liver were measured. Significantly less transaminase and TNF were released into the circulation in mice given the steroid or vitamin E before the endotoxin. In endotoxin-treated animals oestrogen administration did not influence induction of the superoxide dismutase. It is postulated that protection of the liver in these experiments arises from a direct pharmacological antioxidant effect of the oestrogen.
给几组小鼠皮下注射醋酸雌酮或维生素E，以确定这些处理如何改变对腹腔注射内毒素脂多糖的反应。检测肝转氨酶和肿瘤坏死因子（TNF）释放入血清的情况以及肝脏中锰超氧化物歧化酶的诱导情况。在内毒素注射前给予类固醇或维生素E的小鼠中，释放入循环系统的转氨酶和TNF显著减少。在内毒素处理的动物中，给予雌激素并不影响超氧化物歧化酶的诱导。据推测，这些实验中对肝脏的保护源于雌激素直接的药理抗氧化作用。
