Stark J M, Neale M L
Department of Medical Microbiology, University of Wales College of Medicine, Cardiff, U.K.
FEMS Microbiol Immunol. 1991 Nov;3(6):337-40. doi: 10.1111/j.1574-6968.1991.tb04258.x.
Human peripheral blood adherent cells (PBAC) incubated with oestrone in high concentration (10(-5) M) release, on exposure to bacterial endotoxin, an amount of tumour necrosis factor (TNF) greater than do cells incubated without the steroid. The finding may imply a non-endocrine hormonal process leading to heightened local TNF responses. This may be the basis of endotoxin hypersensitivity in pregnancy.
用高浓度（10⁻⁵ M）雌酮孵育的人外周血黏附细胞（PBAC），在暴露于细菌内毒素时，释放的肿瘤坏死因子（TNF）量比未用该类固醇孵育的细胞更多。这一发现可能意味着存在一个导致局部TNF反应增强的非内分泌激素过程。这可能是妊娠期内毒素超敏反应的基础。
