Sullivan M H, Elder M G
Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.
Br J Obstet Gynaecol. 1993 Jun;100(6):542-5. doi: 10.1111/j.1471-0528.1993.tb15305.x.
To determine whether aspirin therapy in women at risk of pre-eclampsia alters in vitro platelet aggregation.
Longitudinal observational study.
RPMS Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London.
Six pregnant women at-risk or with pre-eclampsia.
Women considered to be at risk of pre-eclampsia or with the disorder were treated with aspirin. In vitro platelet aggregation in response to platelet-activating factor (PAF) and adenosine diphosphate (ADP) before and after aspirin therapy were analysed.
Prior to aspirin therapy platelet aggregation was decreased compared with normal pregnant women. After aspirin therapy platelet aggregation in response to PAF and ADP was greater, but did not return to levels associated with normal pregnancy.
In women with pre-existing decreased platelet aggregation suggestive of platelet exhaustion, aspirin increased aggregation. This suggests that aspirin decreases in vivo platelet activation and thereby decreases the platelet exhaustion revealed by the in vitro studies.
确定阿司匹林治疗对有先兆子痫风险的女性体外血小板聚集的影响。
纵向观察性研究。
伦敦哈默史密斯医院RPMS妇产研究所。
6名有先兆子痫风险或患有先兆子痫的孕妇。
将被认为有先兆子痫风险或患有该疾病的女性用阿司匹林进行治疗。分析阿司匹林治疗前后血小板对血小板激活因子（PAF）和二磷酸腺苷（ADP）的体外聚集情况。
与正常孕妇相比，阿司匹林治疗前血小板聚集降低。阿司匹林治疗后，血小板对PAF和ADP的聚集增加，但未恢复到与正常妊娠相关的水平。
对于已有血小板聚集降低提示血小板耗竭的女性，阿司匹林可增加聚集。这表明阿司匹林可降低体内血小板激活，从而降低体外研究显示的血小板耗竭。
