起始因子eIF-2的β亚基在起始复合物形成中的作用。
The role of the beta-subunit of initiation factor eIF-2 in initiation complex formation.
作者信息
Flynn A, Oldfield S, Proud C G
机构信息
Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.
出版信息
Biochim Biophys Acta. 1993 Jul 18;1174(1):117-21. doi: 10.1016/0167-4781(93)90105-m.
PMID:8334162
Abstract
The functional properties of preparations of protein synthesis initiation factor eIF-2 which lack the beta-subunit (as confirmed immunologically) were compared with those of the heterotrimeric factor. The former can bind guanine nucleotides but not initiator tRNA, and also exhibits a substantially reduced rate of initiation factor eIF-2B-mediated GDP/GTP-exchange.
摘要
将缺乏β亚基的蛋白质合成起始因子eIF-2制剂（经免疫学证实）的功能特性与异源三聚体因子的功能特性进行了比较。前者能够结合鸟嘌呤核苷酸，但不能结合起始tRNA，并且起始因子eIF-2B介导的GDP/GTP交换速率也显著降低。
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