Liang D, Li D D
Guangdong Medical College.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 1993 Feb;13(2):86-7, 68.
24 cases of type II nephrotic syndrome were studied and divided randomly into two groups. Group A: 12 cases treated with verapamil; Group B: 12 cases treated with verapamil plus Renal Disease Basic-prescription (RDBP). Hemorheology indexes were measured in the two groups before and 4 weeks after the treatment. The results showed hyperviscosity was obviously improved in group A after verapamil administration (P < 0.05), but the improvement in group B was much more significant than that in group A. The results mentioned above indicate that calcium channel blocker has an anticoagulant effect with inhibiting platelet aggregation, and Peach kernel, Safflower, etc of RDBP played a role in prohibiting platelets aggregation, anticoagulation and promoting microcirculation. However the combination of the two methods has better effect in improving the hypercoagulable state of nephrotic syndrome.
对24例Ⅱ型肾病综合征患者进行研究，并随机分为两组。A组：12例用维拉帕米治疗；B组：12例用维拉帕米加肾病基础方（RDBP）治疗。分别于治疗前及治疗4周后检测两组血液流变学指标。结果显示，A组给予维拉帕米治疗后高黏滞血症明显改善（P<0.05），但B组改善程度明显优于A组。上述结果表明，钙通道阻滞剂具有抗凝作用，能抑制血小板聚集，RDBP中的桃仁、红花等具有抑制血小板聚集、抗凝及促进微循环的作用。然而，两种方法联合应用在改善肾病综合征高凝状态方面效果更佳。
