Yokobayashi T, Nakajima T
J Maxillofac Surg. 1978 Nov;6(4):273-6. doi: 10.1016/s0301-0503(78)80105-2.
A case of osteogenic sarcoma of the maxilla is described. The tumor was excised by a hemimaxillectomy but recurred in 3 months. The patient died 8 months after the initial onset of symptoms. Chemotherapy and radiation were ineffective with the exception of bleomycin, which caused necrosis of the tumour, with no apparent increase in growth, and a decrease of the serum alkaline phosphatase level to less than half of the maximum value. There was a close correlation between the fluctuating pattern of the serum alkaline phosphatase level and the growth and remission of the tumour during the entire course of treatment.
本文描述了一例上颌骨骨肉瘤病例。肿瘤通过半侧上颌骨切除术切除，但在3个月后复发。患者在出现症状8个月后死亡。化疗和放疗均无效，除博来霉素外，博来霉素可导致肿瘤坏死，肿瘤生长无明显增加，血清碱性磷酸酶水平降至最大值的一半以下。在整个治疗过程中，血清碱性磷酸酶水平的波动模式与肿瘤的生长和缓解密切相关。
