Klapholz L, Ackerstein A, Goldenhersh M A, Vardy D, Nagler A
Department of Dermatology, Hadassah University Hospital, Jerusalem, Israel.
Bone Marrow Transplant. 1993 Jun;11(6):443-6.
Immunotherapy using subcutaneous injections of recombinant interleukin-2 (IL-2) and recombinant interferon alpha-2a (IFN-alpha) for advanced hematologic and solid tumors is rapidly developing. We report five patients with Hodgkin's and non-Hodgkin's lymphoma who developed a local cutaneous reaction consisting of inflammatory painful nodules with a central multiloculated vesicle at the site of sc injections of IL-2 and IFN-alpha immunotherapy following ABMT. This is the first report of a local cutaneous adverse reaction induced by IL-2 and IFN-alpha immunotherapy following ABMT.
使用皮下注射重组白细胞介素-2（IL-2）和重组干扰素α-2a（IFN-α）治疗晚期血液系统肿瘤和实体瘤的免疫疗法正在迅速发展。我们报告了5例霍奇金淋巴瘤和非霍奇金淋巴瘤患者，他们在自体骨髓移植（ABMT）后接受IL-2和IFN-α免疫疗法皮下注射部位出现局部皮肤反应，表现为炎症性疼痛结节，中央有多个分隔的水疱。这是关于ABMT后IL-2和IFN-α免疫疗法引起局部皮肤不良反应的首例报告。
