Udupa K B, Reissmann K R
J Lab Clin Med. 1977 Feb;89(2):278-84.
Erythropoietin injection raised within 24 hr. the number of CFU-E in the femoral marrow of polycythemic mice by 837 percent. Endotoxin given at 0 to 24 hr. before erythropoietin nearly abolished this CFU-E increase. Endotoxin in the culture medium did not inhibit erythroid colony formation, but in vivo endotoxin suppressed erythropoietin-induced differentiation of proerythroblasts from their precursors. Endotoxin thus suppresses marrow erythropoiesis either by inhibiting transformation of erythroid precursors into CFU-E or by causing the disappearance, perhaps by emigration, of CFU-E from the marrow.
促红细胞生成素注射在24小时内使真性红细胞增多症小鼠股骨骨髓中的CFU-E数量增加了837%。在内毒素在促红细胞生成素之前0至24小时给予时，几乎消除了这种CFU-E的增加。培养基中的内毒素并不抑制红系集落形成，但体内内毒素抑制促红细胞生成素诱导的早幼红细胞从其前体细胞的分化。因此，内毒素通过抑制红系前体细胞向CFU-E的转化，或者可能通过促使CFU-E从骨髓中迁移出去而导致其消失，从而抑制骨髓红细胞生成。
