Fois A, Calistri L, Balestri P, Vivarelli R, Bartalini G, Mancini L, Berardi A, Vanni M
Clinica Pediatrica, Università degli Studi, Siena, Italy.
Eur J Pediatr. 1993 Jun;152(6):500-4. doi: 10.1007/BF01955059.
We re-examined 21 children with the possible diagnosis of peripheral neurofibromatosis (NF1) based on the presence of café-au-lait (CAL) spots as the single clinical finding. We evaluated whether "typical" or "atypical" appearance of the spots was important for the final diagnosis and whether the co-existence of other non-specific signs (e.g. pectus excavatum) were of any significance for the final diagnosis. In 8/14 (57.1%) cases with "typical" CAL spots, the diagnosis of NF1 was finally established on the basis of other criteria. For the other 6 patients the diagnosis is not yet definitive but highly probable on the basis of the presence of macrocephaly, pectus excavatum and/or MRI findings. Only one patient among five with "atypical" CAL spots possibly has NF1.
